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RU58841 Solution – 50 ml PG free


44.9092.50 Inc. VAT

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  • Additional information



The PG Free solution contains glycerin (plant based/halal) instead of propylene glycol, which is a hypoallergenic skin moisturizer, very similar to

What is Pyrilutamide?

Pyrilutamide (KX-826), often used as a pyrilutamide solution, is a nonsteroidal anti androgen, or more specifically, a selective high-affinity silent antagonist of the androgen receptor, which is researched now for the potential treatment of androgenetic alopecia in males and females. Pyrilutamide binds to the androgen receptor with a very high affinity with an IC50 of 0.28nM.

Pyrilutamide has very similar properties as RU58841, but it is a way more refined and stronger version. Pyrilutamide is a very well tolerable, with very few systemic side effects. From anecdotal and indoor research, there were no significant side effects to note with dosages up to 5 mg per day, whilst hair loss was significantly reduced within the first week. This makes a huge promise for the treatment of androgenic alopecia, and specifically diffuse androgenic alopecia, which is a very hard to treat form of androgenic alopecia. Both RU58841 and pyrilutamide are very effective chemicals to stop hair loss from androgenic alopecia. As with everything, there is no one-size-fits all solution for androgenic alopecia, but pyrilutamide comes very close to this.

If you struggle with a burning and itchy sensation on your scalp, we really recommend to add our new product to your regimen: ActiFolic CALM, with GHK-Cu (copper peptide)

Q: What Are Essential Oils?

A: Essential oils are proven to help against hair loss. Our solutions that are enriched with essential oils, will increase circulation in the scalp similar to the effects of Minoxidil, but without a shedding phase and other Minoxidil related side effects. Our solution contain peppermint oil, tea tree oil and lavender oil. These essential oils alone work great for reducing hair loss and reduce scalp inflammation. The combined oils make a synergic effect, that will calm down the inflamed scalp, increase circulation and stimulate hair follicles.  When applied, the scalp will immediately feel calmed down, due to the cooling and inflammation reducing effect of essential oils.

Q: What is OctoPirox (Piroctone Olamine)?

A: OctoPirox, also known as piroctone olamine, is a chemical very much related to ketoconazole. It has proven its efficacy in various studies

Compared to ketoconazole, Piroctone Olamine increases the number of hairs in the growth phase (anagen phase) by more than 10% in 33% more people.

Q: In what vehicle is the pyrilutamide dissolved?

A: It’s dissolved in ethanol/propylene glycol

Q: I need to cover my full scalp, but I can’t get it done with 1 ml (5mg).

A: We recommend to dilute the solution. So add 30 ml Ethanol/PG solution to your 0.5% pyrilutamide 30 ml solution. This will make a 60 ml pyrilutamide solution at 0.25% strength. For convenience, we recommend this 60 ml mixing bottle. Using 2 ml of the 0.25% strength should be enough to cover the full scalp, which is a total daily dose of 5 mg, which was used in the research papers.

Chemical Info

CAS Number: 1272719-00-2
Molecular Formula: C21H15F5N4O2S


Molecular Weight: 482.429 g/mol
Storage: Liquids have to be stored in room temperature, not refrigerated, out of direct sunlight. Shelf life of liquids is >12 months. Unused raw powders are best stored in a zip lock bag in the freezer (-19°C) for optimal shelf life (36 months). Raw powders stored in room temperature are stable up to 18 months. After 18 months the chemical will slowly degrade.

Safety Recommendations
Safety Measures: View
Material Safety Data Sheet: View 

Additional information


3%, 5% (mostly used), 8%, 3% + Essential Oils, 5% + Essential Oils, 8% + Essential Oils, 3% + Essential Oils + OctoPirox + Biotin/Niacinamide/Caffeine, 5% + Essential Oils + OctoPirox + Biotin/Niacinamide/Caffeine (recommended), 8% + Essential Oils + OctoPirox + Biotin/Niacinamide/Caffeine

1 review for RU58841 Solution – 50 ml PG free

  • Roe Jogan

    July 12, 2022 at 10:32 pm

    5 out of 5

    Thicker than PG, but no dandruff nor itchiness thanks to the VG, this is better for rats with sensitive scalps, note that a spray bottle will squirt a stream of liquid.


    • actifolic

      July 12, 2022 at 10:34 pm

      Do you wish to have a thinner solution in future orders? We are currently using 25% glycerin with 75% ethanol.


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