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Topical S4 (Andarine) – 30 ml


39.9043.90 Inc. VAT

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S4 (andarine) Solution

What is S4 / Andarine?

Andarine is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy, using the nonsteroidal antiandrogen bicalutamide as a lead compound.

Recently it became more clear that topical SARMs do have a place in a hair loss regimen and for some individuals probably a better alternative compared to traditional treatments, due to the fact that it does not produce a anti androgenic reactie. Some individuals are unlucky and can not tolerate any topical anti androgens.
A SARM can bind to the androgen receptor and instead of producing an anti androgenic reaction, the SARM will occupy the androgen receptor and produce a slightly anabolic reaction, when the chemical is released in the bloodstream due to topical application. This can be a huge benefit, because masculanity of the person is kept the same and not anti androgenic activity will take place.

What Are Essential Oils?

Essential oils are proven to help against hair loss. Our solutions that are enriched with essential oils, will increase circulation in the scalp similar to the effects of Minoxidil, but without a shedding phase and other Minoxidil related side effects. Our solution contain pepermint oil, tea tree oil and lavender oil. These essential oils alone work great for reducing hair loss and recude scalp inflammation. The combined oils make a synergic effect, that will calm down the inflammed scalp, increase circulation and stimulate hair follicles.  When applied, the scalp will immediately feel calmed down, due to the cooling and inflammation reducing effect of essential oils.

What is OctoPirox (Piroctone Olamine)?

OctoPirox, also known as piroctone olamine, is a chemical very much related to ketoconazole. It has proven its effeciacy in various studies. One of these studies is summarized here below.

A study of 150 men with androgenic alopecia and dandruff compared Ketoconazole and Piroctone Olamine. Excessive sebum secretion, dandruff and seborrheic eczema are often associated with hair loss and androgenic alopecia. The 150 men were given a shampoo containing 1% Ketoconazole or 1% Piroctone Olamine. They had to use this shampoo 2-3 times a week for six months.

Both treatments showed a reduction in itching and dandruff after two to six weeks. Looking at the effect of the treatments on different hair growth parameters, the following figures (in percentages) can be seen:

  • Hair loss decreases: (Ketoconazole: -17.3%, Piroctone Olamine: -16.5%)
  • The percentage of hair in the growth phase increases: (Ketoconazole 4.9%, Piroctone Olamine: 7.9%).
  • The hair diameter increases: (5.4% increase with Ketoconazole and 7.7% with Piroctone Olamine)
  • The study thus shows that Piroctone Olamine scores better than Ketoconazole on a number of levels.

Compared with Ketoconazole, Piroctone Olamine increases the number of hairs in the growth phase (anagen phase) by more than 10% in 33% more people.
With Piroctone Olamine, 88% of people get increased hair thickness, despite androgenic alopecia, whereas with Ketoconazole this is 78%.

Source: Pierard-Franchimont, C., Goffin, V., Henry, F., Uhoda, I., Braham, C., & Pierard, G.E. (2002). Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% Piroctone olamine and 1% zinc pyrithione formulations. International Journal of Cosmetic Science, 2002, 24, 249-256.

The information on this page is purely for information purposes only and should be read in a research context. 

Additional information


3%, 5%, 3% + Essential Oils & OctoPirox, 5% + Essential Oils & OctoPirox


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